The ALS-inducing factors, TDP43^A315T and SOD1^G93A, directly affect and sensitize sensory neurons to stress.

ABSTRACT: There is increased recognition that sensory neurons located in dorsal root ganglia (DRG) are affected in amyotrophic lateral sclerosis (ALS). However, it remains unknown whether ALS-inducing factors, other than mutant superoxide dismutase 1 (SOD1^G93A), directly affect sensory neurons. Here, we examined the effect of mutant TAR DNA-binding protein 1 (TDP43^A315T) on sensory neurons in culture and in vivo. In parallel, we reevaluated sensory neurons expressing SOD1^G93A. We found that cultured sensory neurons harboring either TDP43^A315T or SOD1^G93A grow neurites at a slower rate and elaborate fewer neuritic branches compared to control neurons. The presence of either ALS-causing mutant gene also sensitizes sensory neurons to vincristine, a

SUBMITTER: Vaughan SK 

PROVIDER: S-EPMC6224462 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature