Altered Placental Chorionic Arterial Biomechanical Properties During Intrauterine Growth Restriction.

ABSTRACT: Intrauterine growth restriction (IUGR) is a pregnancy complication due to placental dysfunction that prevents the fetus from obtaining enough oxygen and nutrients, leading to serious mortality and morbidity risks. There is no treatment for IUGR despite having a prevalence of 3% in developed countries, giving rise to an urgency to improve our understanding of the disease. Applying biomechanics investigation on IUGR placental tissues can give important new insights. We performed pressure-diameter mechanical testing of placental chorionic arteries and found that in severe IUGR cases (RI > 90^th centile) but not in IUGR cases (RI < 90^th centile), vascular distensibility was significantly increased from normal. Constitutive modeling demonstrated that a simplified Fung-type

SUBMITTER: Saw SN 

PROVIDER: S-EPMC6224524 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature