PET imaging reveals lower kappa opioid receptor availability in alcoholics but no effect of age.

ABSTRACT: Opioid receptors are implicated in alcoholism, other addictions, withdrawal, and depression, and are considered potential pharmacological targets for treatment. Our goal in the present study was to compare the availability of kappa opioid receptors (KOR) between an alcohol-dependent cohort (AD) and a healthy control cohort (HC). Sixty-four participants-36 AD and 28 HC-underwent PET scans with [¹¹C]LY2795050, a selective kappa antagonist tracer. Partial-volume correction was applied to all PET data to correct for atrophy. Volume of distribution (V_T) of the tracer was estimated regionally as a measure of KOR availability. V_T values of AD versus HC were compared for 15 defined ROIs. Multivariate analysis showed a main effect of group on V_T across th

SUBMITTER: Vijay A 

PROVIDER: S-EPMC6224533 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature