Genome-wide associations for benign prostatic hyperplasia reveal a genetic correlation with serum levels of PSA.

ABSTRACT: Benign prostatic hyperplasia and associated lower urinary tract symptoms (BPH/LUTS) are common conditions affecting the majority of elderly males. Here we report the results of a genome-wide association study of symptomatic BPH/LUTS in 20,621 patients and 280,541 controls of European ancestry, from Iceland and the UK. We discovered 23 genome-wide significant variants, located at 14 loci. There is little or no overlap between the BPH/LUTS variants and published prostate cancer risk variants. However, 15 of the variants reported here also associate with serum levels of prostate specific antigen (PSA) (at a Bonferroni corrected P < 0.0022). Furthermore, there is a strong genetic correlation, r_g = 0.77 (P = 2.6 × 10^-11), between PSA and BPH/LUTS, and one standard deviatio

SUBMITTER: Gudmundsson J 

PROVIDER: S-EPMC6224563 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature