Striatal activity correlates with stimulant-like effects of alcohol in healthy volunteers.

ABSTRACT: Individuals who experience greater stimulation and less sedation from alcohol are at increased risk for alcohol-related problems. However, little is known regarding the neurobiological mechanisms underlying subjective response to alcohol. The current study examined the degree to which alcohol-induced brain activation correlates with ratings of stimulation and sedation, using a within-subjects, double-blind, placebo-controlled design. Participants (N = 34 healthy adults with no history of alcohol use disorder) completed three sessions: a calibration session to determine the duration of infusion needed to bring the breath alcohol to 80 mg/dl for each subject, and two counterbalanced fMRI sessions with placebo and alcohol administration. During the fMRI sessions, participants underwent 50 min

SUBMITTER: Weafer J 

PROVIDER: S-EPMC6224577 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature