Unlimited sucrose consumption during adolescence generates a depressive-like phenotype in adulthood.

ABSTRACT: Depression is highly prevalent worldwide, but its etiology is not fully understood. An overlooked possible contributor to the epidemic of depression is feeding styles, particularly at early age when the brain is intensely changing. We have previously reported that unlimited sucrose consumption during adolescence leads to enduring changes in brain reward function. Here, we tested the hypothesis that sucrose consumption during adolescence would lead to a 'depressive-like' phenotype. Adolescent male rats were given unlimited access to 5% sucrose in their home cages from postnatal day 30 to postnatal day 46 and their emotional behavior was subsequently examined at adulthood. Sucrose consumption during adolescence caused anhedonia, decreased motivation for saccharin, increased immobility in the

SUBMITTER: Gueye AB 

PROVIDER: S-EPMC6224580 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature