Mitochondrial respiratory chain function and content are preserved in the skeletal muscle of active very old men and women.

ABSTRACT:

Introduction

The loss of mitochondrial function and content have been implicated in sarcopenia although they have been little studied in the very old, the group in which sarcopenia is most common. In this pilot study, our aim was to determine if mitochondrial respiratory chain function and content are preserved among healthy 85-year-olds.

Methods

We recruited 19 participants (11 female) through their general practitioner and assessed their medical history, functional status and self-reported physical activity. We identified sarcopenia using grip strength, Timed Up-and-Go and bioimpedance analysis. We assessed mitochondrial respiratory chain function using phosphorous magnetic resonance spectroscopy, estimating τ_1/2 PCr, the recovery half-time of phosphocreatine in

SUBMITTER: Dodds RM 

PROVIDER: S-EPMC6224654 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature