Urinary Plasmin(ogen) as a Prognostic Factor for Hypertension.

ABSTRACT:

Introduction

Plasmin and its precursor, plasminogen, are detectable in urine from patients with glomerular disease. Urinary plasmin(ogen) levels correlate with blood pressure (BP) and may contribute to renal Na⁺ retention by activating the epithelial Na⁺ channel (ENaC). In a longitudinal nested-cohort study, we asked whether urinary plasmin(ogen) levels predict subsequent increase in BP, incident hypertension, or mortality in subjects with type I diabetes, who often develop proteinuria.

Methods

The Pittsburgh Epidemiology of Diabetes Complications (EDC) study followed up type I diabetic subjects for 25 years. Urine specimens from 70 subjects with a spectrum of baseline urinary albumin levels were examined. Outcomes included increased BP after 2 years (≥

SUBMITTER: Ray EC 

PROVIDER: S-EPMC6224670 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature