Impact of Acute Kidney Injury and CKD on Adverse Outcomes in Critically Ill Septic Patients.

ABSTRACT:

Introduction

Chronic kidney disease (CKD) and acute kidney injury (AKI) are strongly associated with excess morbidity and mortality and frequently co-occur in critically ill septic patients, but how their interplay affects clinical outcomes is not well elucidated.

Methods

We conducted a single-center, retrospective cohort study of 2632 adult patients admitted to the intensive care unit (ICU) with severe sepsis or septic shock. Subjects were classified into 6 groups according to baseline CKD (no-CKD: estimated glomerular filtration rate [eGFR] ≥60; CKD: eGFR 15-59 ml/min per 1.73 m²) and incident AKI by the Kidney Disease: Improving Global Outcomes (KDIGO) serum creatinine criteria (no-AKI, AKI stage 1, AKI stages ≥2) during ICU stay. Study outcomes were 90-day mor

SUBMITTER: Neyra JA 

PROVIDER: S-EPMC6224792 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature