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ABSTRACT: Aims
We assessed the association between smoking status and mild cognitive impairment (MCI) in Japanese diabetic patients.Methods
This cross-sectional study included 323 diabetic patients, aged 40-79 years, who were referred to an outpatient diabetic clinic between January and July 2013 at Shiga University of Medical Science Hospital (Otsu, Japan). Cognitive function was assessed using the mini-mental state examination (MMSE), and patients were classified into two categories: normal cognitive function (MMSE score ≥27) and MCI (MMSE score 22-26). Logistic regression analysis was used to estimate the multivariable-adjusted odds ratios (ORs) and 95 % confidence intervals (CIs) for MCI in current smokers and ex-smokers compared with never-smokers.Results
Of the 323 patients, 55 (17.0 %), 134 (41.5 %), and 134 (41.5 %) were current smokers, ex-smokers, and never-smokers, respectively. Of these, 68 (21.0 %) patients had MCI. After adjusting for age, sex, systolic blood pressure, body mass index, high-density lipoprotein cholesterol, estimated glomerular filtration rate, hemoglobin A1c, insulin therapy, sulfonylurea, history of coronary heart disease, exercise habit, drinking status, and education, the OR for MCI was 3.62 (95 % CI 1.26-10.40) in current smokers compared with never-smokers. In addition, the multivariable-adjusted ORs for MCI were 3.02 (95 % CI 0.64-14.32) in current smokers <30.0 pack-years and 4.90 (95 % CI 1.32-18.16) in current smokers ≥30.0 pack-years, compared with never-smokers (p for trend = 0.017).Conclusions
Current smoking, especially current smoking for which cumulative lifetime exposure was high, was associated with MCI, as assessed using the MMSE in Japanese diabetic patients.
SUBMITTER: Sonoda N
PROVIDER: S-EPMC6224970 | biostudies-literature | 2016 Dec
REPOSITORIES: biostudies-literature
Sonoda Nao N Morimoto Akiko A Ugi Satoshi S Morino Katsutaro K Sekine Osamu O Nemoto Ken-Ichi KI Maegawa Hiroshi H Miyamatsu Naomi N
Diabetology international 20160203 4
<h4>Aims</h4>We assessed the association between smoking status and mild cognitive impairment (MCI) in Japanese diabetic patients.<h4>Methods</h4>This cross-sectional study included 323 diabetic patients, aged 40-79 years, who were referred to an outpatient diabetic clinic between January and July 2013 at Shiga University of Medical Science Hospital (Otsu, Japan). Cognitive function was assessed using the mini-mental state examination (MMSE), and patients were classified into two categories: nor ...[more]