A comparison of IDeg + IAsp versus IDet + IAsp in subjects with type 1 diabetes: subgroup analysis of Japanese subjects.

ABSTRACT:

Objective

Efficacy and safety were compared between insulin degludec (IDeg) once daily (OD) in combination with mealtime insulin aspart (IAsp) and insulin detemir (IDet) OD or twice daily (BID) in combination with mealtime IAsp in Japanese subjects with type 1 diabetes mellitus (T1DM).

Materials and methods

This was a post hoc analysis of a multinational, controlled, open-label, parallel-group, treat-to-target trial that randomised adults [aged ≥18 years (≥20 years for Japan)] with T1DM for ≥12 months to basal IDeg OD (n = 124) or IDet (n = 62), both with mealtime bolus IAsp. The IDet dosing was adjusted to BID if required at ≥8 weeks.

Results

The estimated mean change in HbA_1c from baseline to week 26 (the primary outcome measure) was -1.03 %

SUBMITTER: Ono Y 

PROVIDER: S-EPMC6224976 | biostudies-literature | 2016 Dec

REPOSITORIES: biostudies-literature