Design, Synthesis, Phloem Mobility, and Bioactivities of a Series of Phenazine-1-Carboxylic Acid-Amino Acid Conjugates.

ABSTRACT: Developing fungicides with phloem mobility that can be applied to leaves to control root or vascular pathogens has long been desirable. To achieve this goal, an efficient and economical strategy involves introducing an amino acid into the existing highly active parent pesticide molecule. Hence, 12 L-phenazine-1-carboxylic acid (PCA)-amino acid conjugates 4a⁻l were designed and synthesized via a simple synthetic route. In vitro bioassays results showed that all synthesized compounds 4a⁻l exhibited certain fungicidal activities against six tested fungi. Compound 4c exhibited relatively good fungicidal activity against Rhizoctonia solani, and the EC₅₀ value was 0.084 ± 0.006 mmol/L. The phloem mobility experiments revealed that introducing

SUBMITTER: Yu L 

PROVIDER: S-EPMC6225111 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature