Gastroprotective Activity of Parastrephia quadrangularis (Meyen), Cabrera from the Atacama Desert.

ABSTRACT: Forty-three metabolites including several methoxylated flavonoids, tremetones, and ent-clerodane diterpenes were accurately identified for the first time in the ethanolic extract of P. quadrangularis by means of hyphenated UHPLC-quadrupole Orbitrap mass spectrometry, and seven isolated compounds were tested regarding gastroprotective activity using the HCl/EtOH-induced lesion model in mice. A new tremetone (compound 6) is reported based on spectroscopic evidence. The isolated clerodanes and tremetones showed gastroprotective activity in a mouse model, evidenced by compound 7 (p-coumaroyloxytremetone), which showed the highest gastroprotective activity (76%), which was higher than the control drug lansoprazole (72%). Our findings revealed that several cons

SUBMITTER: Ardiles A 

PROVIDER: S-EPMC6225235 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature