Natural Scaffolds with Multi-Target Activity for the Potential Treatment of Alzheimer's Disease.

ABSTRACT: A few symptomatic drugs are currently available for Alzheimer's Disease (AD) therapy, but these molecules are only able to temporary improve the cognitive capacity of the patients if administered in the first stages of the pathology. Recently, important advances have been achieved about the knowledge of this complex condition, which is now considered a multi-factorial disease. Researchers are, thus, more oriented toward the preparation of molecules being able to contemporaneously act on different pathological features. To date, the inhibition of acetylcholinesterase (AChE) and of β-amyloid (Aβ) aggregation as well as the antioxidant activity and the removal and/or redistribution of metal ions at the level of the nervous system are the most common investigated targets for the treatment of A

SUBMITTER: Piemontese L 

PROVIDER: S-EPMC6225478 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature