Biodistribution and Radiation Dosimetry of ¹²⁴I-DPA-713, a PET Radiotracer for Macrophage-Associated Inflammation.

ABSTRACT: Whole-body PET/CT was performed using ¹²⁴I-DPA-713, a radioligand for the 18-kDa translocator protein (TSPO), to determine biodistribution and radiation dosimetry. Methods: Healthy subjects aged 18-65 y underwent whole-body PET/CT either at 4, 24, and 48 h or at 24, 48, and 72 h after intravenous injection of ¹²⁴I-DPA-713. Time-activity curves were generated and used to calculate organ time-integrated activity coefficients for each subject. The resulting time-integrated activity coefficients provided input data for calculation of organ absorbed doses and effective dose for each subject using OLINDA. Subjects were genotyped for the TSPO polymorphism rs6971, and plasma protein binding of ¹²⁴I-DPA-713 was measured. Results: Three male and

SUBMITTER: Foss CA 

PROVIDER: S-EPMC6225541 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature