⁹⁰Y-DOTATOC Dosimetry-Based Personalized Peptide Receptor Radionuclide Therapy.

ABSTRACT: Pretherapy PET with ⁸⁶Y-DOTATOC is considered the ideal dosimetry protocol for ⁹⁰Y-DOTATOC therapy; however, its cost, limited availability, and need for infusion of amino acids to mimic the therapy administration limit its use in the clinical setting. The goal of this study was to develop a dosimetric method for ⁹⁰Y-DOTATOC using ⁹⁰Y-DOTATOC PET/CT and bremsstrahlung SPECT/CT and to determine whether dosimetry-based administered activities differ significantly from standard administered activities. Methods: This was a prospective phase 2 trial of ⁹⁰Y-DOTATOC therapy in patients with somatostatin receptor-positive tumors. ⁹⁰Y-DOTATOC was given in 3 cycles 6-8 wk apart. In the first cycle of therapy, adults received 4.

SUBMITTER: Menda Y 

PROVIDER: S-EPMC6225542 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature