Evaluation of pancreatic tumor development in KPC mice using multi-parametric MRI.

ABSTRACT:

Background

Pancreatic ductal adenocarcinoma (PDA) is a fatal disease with very poor prognosis. Development of sensitive and noninvasive methods to monitor tumor progression in PDA is a critical and unmet need. Magnetic resonance imaging (MRI) can noninvasively provide information regarding underlying pathophysiological processes such as necrosis, inflammatory changes and fibrotic tissue deposition.

Methods

A genetically engineered KPC mouse model that recapitulates human PDA was used to characterize disease progression. MR measures of T₁ and T₂ relaxation times, magnetization transfer ratio (MTR), diffusion and chemical exchange saturation transfer were compared in two separate phases i.e. slow and rapid growth phase of tumor. Fibrotic tissue accumulati

SUBMITTER: Vohra R 

PROVIDER: S-EPMC6225661 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature