Serotonin induced hepatic steatosis is associated with modulation of autophagy and notch signaling pathway.

ABSTRACT:

Background

Besides its neurotransmitter and vasoconstriction functions, serotonin is an important mediator of numerous biological processes in peripheral tissues including cell proliferation, steatosis, and fibrogenesis. Recent reports indicate that serotonin may promote tumor growth in liver cancer, however, the molecular mechanisms remain elusive. n this study, we investigated the role and molecular signaling mechanisms mediated by serotonin in liver cancer cell survival, drug resistance, and steatosis.

Methods

Effect of serotonin on modulation of cell survival/proliferation was determined by MTT/WST1 assay. Effect of serotonin on the regulation of autophagy biomarkers and lipid/fatty acid proteins expression, AKT/mTOR and Notch signaling was evaluated by immunoblotting. T

SUBMITTER: Niture S 

PROVIDER: S-EPMC6225666 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature