Association of sex hormone-binding globulin with nonalcoholic fatty liver disease in Chinese adults.

ABSTRACT:

Background

Sex hormone-binding globulin (SHBG), a glycoprotein synthesized by hepatocytes, has been linked to insulin resistance and hepatic lipid metabolism and is suggested to be associated with nonalcoholic fatty liver disease (NAFLD). This study aimed to investigate the association of SHBG with NAFLD in Chinese adults.

Methods

We conducted a community-based, cross-sectional study in China involving 2912 participants aged 40-75 years old. All participants underwent detection for hepatic fat infiltration by ultrasound in addition to providing complete medical history and undergoing physical and blood biochemical examinations. The association of serum SHBG with the presence of NAFLD was reported by adjusted odds ratio after applying logistic regression models. To further ex

SUBMITTER: Luo J 

PROVIDER: S-EPMC6225668 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature