Exposure to mild blast forces induces neuropathological effects, neurophysiological deficits and biochemical changes.

ABSTRACT: Direct or indirect exposure to an explosion can induce traumatic brain injury (TBI) of various severity levels. Primary TBI from blast exposure is commonly characterized by internal injuries, such as vascular damage, neuronal injury, and contusion, without external injuries. Current animal models of blast-induced TBI (bTBI) have helped to understand the deleterious effects of moderate to severe blast forces. However, the neurological effects of mild blast forces remain poorly characterized. Here, we investigated the effects caused by mild blast forces combining neuropathological, histological, biochemical and neurophysiological analysis. For this purpose, we employed a rodent blast TBI model with blast forces below the level that causes macroscopic neuropathological changes. We found that

SUBMITTER: Hernandez A 

PROVIDER: S-EPMC6225689 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature