Cow-to-mouse fecal transplantations suggest intestinal microbiome as one cause of mastitis.

ABSTRACT:

Background

Mastitis, which affects nearly all lactating mammals including human, is generally thought to be caused by local infection of the mammary glands. For treatment, antibiotics are commonly prescribed, which however are of concern in both treatment efficacy and neonate safety. Here, using bovine mastitis which is the most costly disease in the dairy industry as a model, we showed that intestinal microbiota alone can lead to mastitis.

Results

Fecal microbiota transplantation (FMT) from mastitis, but not healthy cows, to germ-free (GF) mice resulted in mastitis symptoms in mammary gland and inflammations in serum, spleen, and colon. Probiotic intake in parallel with FMT from diseased cows led to relieved mastitis symptoms in mice, by shifting the murine intestinal micro

SUBMITTER: Ma C 

PROVIDER: S-EPMC6225715 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature