Recent Advances in Our Understanding of the Biosynthesis of Sulfur Modifications in tRNAs.

ABSTRACT: Sulfur is an essential element in all living organisms. In tRNA molecules, there are many sulfur-containing nucleosides, introduced post-transcriptionally, that function to ensure proper codon recognition or stabilization of tRNA structure, thereby enabling accurate and efficient translation. The biosynthesis of tRNA sulfur modifications involves unique sulfur trafficking systems that are closely related to cellular sulfur metabolism, and "modification enzymes" that incorporate sulfur atoms into tRNA. Herein, recent biochemical and structural characterization of the biosynthesis of sulfur modifications in tRNA is reviewed, with special emphasis on the reaction mechanisms of modification enzymes. It was recently revealed that TtuA/Ncs6-type 2-thiouridylases from thermophilic bacteria/archae

SUBMITTER: Shigi N 

PROVIDER: S-EPMC6225789 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature