M⁶A facilitates hippocampus-dependent learning and memory through YTHDF1.

ABSTRACT: N⁶-methyladenosine (m⁶A), the most prevalent internal RNA modification on mammalian messenger RNAs, regulates the fates and functions of modified transcripts through m⁶A-specific binding proteins^1-5. In the nervous system, m⁶A is abundant and modulates various neural functions^6-11. Whereas m⁶A marks groups of mRNAs for coordinated degradation in various physiological processes^12-15, the relevance of m⁶A for mRNA translation in vivo remains largely unknown. Here we show that, through its binding protein YTHDF1, m⁶A promotes protein translation of target transcripts in response to neuronal stimuli in the adult mouse hippocampus, thereby facilitating learning and memory. Mice with gen

SUBMITTER: Shi H 

PROVIDER: S-EPMC6226095 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature