Highly parallel, interferometric diffusing wave spectroscopy for monitoring cerebral blood flow dynamics.

ABSTRACT: Light-scattering methods are widely used in soft matter physics and biomedical optics to probe dynamics in turbid media, such as diffusion in colloids or blood flow in biological tissue. These methods typically rely on fluctuations of coherent light intensity, and therefore cannot accommodate more than a few modes per detector. This limitation has hindered efforts to measure deep tissue blood flow with high speed, since weak diffuse light fluxes, together with low single-mode fiber throughput, result in low photon count rates. To solve this, we introduce multimode fiber (MMF) interferometry to the field of diffuse optics. In doing so, we transform a standard complementary metal-oxide-semiconductor (CMOS) camera into a sensitive detector array for weak light fluxes that probe deep in biolog

SUBMITTER: Zhou W 

PROVIDER: S-EPMC6226099 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature