Fetuin-A protein distribution in mature inflamed and ischemic brain tissue.

ABSTRACT:

Background

The liver-derived plasma protein fetuin-A is strongly expressed during fetal life, hence its name. Fetuin-A protein is normally present in most fetal organs and tissues, including brain tissue. Fetuin-A was neuroprotective in animal models of cerebral ischemia and lethal chronic inflammation, suggesting a role beyond the neonatal period. Little is known, however, on the presence of fetuin-A in mature human brain tissue under different physiological and pathological conditions.

Methods

We studied by immunohistochemistry (IHC) the distribution of fetuin-A protein in mature human brain autopsy tissues from patients without neurological disease, patients with inflammatory brain disorders, and patients with ischemic brain lesions. To identify fetuin-A-positive cells in

SUBMITTER: Heinen MC 

PROVIDER: S-EPMC6226147 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature