Dynamic modulation of DC-SIGN and FcΥR2A receptors expression on platelets in dengue.

ABSTRACT: Platelet activation has been reported to play a major role in inflammatory response and thrombocytopenia during dengue viral infection. Cells expressing FcϒR2Aand DC-SIGN receptors are reported to be involved in dengue virulence. The present study is designed to assess the expression level of these two receptors on platelet surface collected from dengue patients and to study its association in patients with platelet RNA positive for dengue virus. This was an analytical cross-sectional study carried out in JIPMER hospital, Puducherry. Forty-four patients with dengue infection as cases and 44 patients with non dengue acute other febrile illness(OFI) as controls were recruited. Peripheral venous blood was withdrawn on day of admission, day 3 post admission and day of discharge and serological

SUBMITTER: Tomo S 

PROVIDER: S-EPMC6226166 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature