Anxiety and depression in Klinefelter syndrome: The impact of personality and social engagement.

ABSTRACT: Klinefelter syndrome (KS) (47, XXY) is the most common sex chromosome disorder, with a prevalence of 1 in every 660 newborn males. Despite the profound adverse effects of anxiety and depression, and their greater prevalence in KS populations, no research has been conducted to date to identify the determinants of anxiety and depression among patients with KS. We examined the relationships between personality traits, social engagement, and anxiety and depression symptoms among KS patients (n = 69) and a group of male controls (n = 69) matched for age and years of education. KS patients experienced more anxiety and depression symptoms than control participants. Neuroticism was the strongest and most consistent mediator between KS and both anxiety and depression symptoms. This research suggest

SUBMITTER: Skakkebæk A 

PROVIDER: S-EPMC6226182 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature