Expression and localisation of thymosin beta-4 in the developing human early fetal heart.

ABSTRACT:

Background

The objective of this study was to investigate the expression and localisation of thymosin β4 (Tβ4) in the developing human heart. Tβ4 is a cardioprotective protein which may have therapeutic potential. While Tβ4 is an endogenously produced protein with known importance during development, its role within the developing human heart is not fully understood. Elucidating the localisation of Tβ4 within the developing heart will help in understanding its role during cardiac development and is crucial for understanding its potential for cardioprotection and repair in the adult heart.

Methods

Expression of Tβ4 mRNA in the early fetal human heart was assessed by PCR using both ventricular and atrial tissue. Fluorescence immunohistochemistry was used to assess the localisa

SUBMITTER: Saunders V 

PROVIDER: S-EPMC6226193 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature