Progressive myocardial injury is associated with mortality in the acute respiratory distress syndrome.

ABSTRACT:

Purpose

Myocardial injury connotes worse prognosis in the Acute Respiratory Distress Syndrome (ARDS), however the prognostic connotation of changes in cardiac troponin (cTn) levels in ARDS patients is not known.

Methods

We performed a study of 908 ARDS patients enrolled in two previously completed ARDS Network trials. We obtained plasma samples via the NIH BIOLINCC repository and measured cTn using the ARCHITECT STAT high sensitivity troponin-I assay (Abbott Laboratories) at trial day 0 and 3. We constructed Cox proportional hazard models to determine the association between 60-day mortality and quintiles of percentage change in high-sensitivity troponin (ΔhsTnI).

Results

The median percent change in hsTnI (%ΔhsTnI) from day 0 to day 3 was -58.2% (IQR -79.0 to 0%). Af

SUBMITTER: Metkus TS 

PROVIDER: S-EPMC6226321 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature