Inflammation-induced Id2 promotes plasticity in regulatory T cells.

ABSTRACT: T_H17 cells originating from regulatory T (T_reg) cells upon loss of the T_reg-specific transcription factor Foxp3 accumulate in sites of inflammation and aggravate autoimmune diseases. Whether an active mechanism drives the generation of these pathogenic 'ex-Foxp3 T_H17' cells, remains unclear. Here we show that pro-inflammatory cytokines enhance the expression of transcription regulator Id2, which mediates cellular plasticity of T_reg into ex-Foxp3 T_H17 cells. Expression of Id2 in in vitro differentiated iT_reg cells reduces the expression of Foxp3 by sequestration of the transcription activator E2A, leading to the induction of T_H17-related cytokines. T_reg-specific ectopic expression of Id2 in mi

SUBMITTER: Hwang SM 

PROVIDER: S-EPMC6226514 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature