Potential effect of household contact management on childhood tuberculosis: a mathematical modelling study.

ABSTRACT:

Background

Tuberculosis is recognised as a major cause of morbidity and mortality in children, with most cases in children going undiagnosed and resulting in poor outcomes. Household contact management, which aims to identify children with active tuberculosis and to provide preventive therapy for those with HIV or those younger than 5 years, has long been recommended but has very poor coverage globally. New guidelines include widespread provision of preventive therapy to children with a positive tuberculin skin test (TST) who are older than 5 years.

Methods

In this mathematical modelling study, we provide the first global and national estimates of the impact of moving from zero to full coverage of household contact management (with and without preventive therapy for TST-posi

SUBMITTER: Dodd PJ 

PROVIDER: S-EPMC6227381 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature