Intrinsic limits of information transmission in biochemical signalling motifs.

ABSTRACT: All living things have evolved to sense changes in their environment in order to respond in adaptive ways. At the cellular level, these sensing systems generally involve receptor molecules at the cell surface, which detect changes outside the cell and relay those changes to the appropriate response elements downstream. With the advent of experimental technologies that can track signalling at the single-cell level, it has become clear that many signalling systems exhibit significant levels of 'noise,' manifesting as differential responses of otherwise identical cells to the same environment. This noise has a large impact on the capacity of cell signalling networks to transmit information from the environment. Application of information theory to experimental data has found that all systems

SUBMITTER: Suderman R 

PROVIDER: S-EPMC6227803 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature