Modeling liver fluke transmission in northeast Thailand: Impacts of development, hydrology, and control.

ABSTRACT: Human infection with the Southeast Asian liver fluke Opisthorchis viverrini and liver fluke-associated cholangiocarcinoma cause significant disease burden in Southeast Asia. While there has been considerable work to understand liver fluke pathology and to reduce infection prevalence, there remains a limited understanding of the environmental determinants of parasite transmission dynamics to inform treatment and control programs. A particular setting where targeted control efforts have taken place is the Lawa Lake complex in northeast Thailand. Here, we describe the recent history of host infections, as well as the hydrologic characteristics of this floodplain ecosystem that influence the extent of snail habitat and fish mobility and the transport of human waste and parasite cercariae. Usin

SUBMITTER: Leon TM 

PROVIDER: S-EPMC6230253 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature