Atypical Functional Connectivity of Amygdala Related to Reduced Symptom Severity in Children With Autism.

ABSTRACT:

Objective

Converging evidence indicates that brain abnormalities in autism spectrum disorders (ASDs) involve atypical network connectivity. Given the central role of social deficits in the ASD phenotype, this investigation examined functional connectivity of the amygdala-a brain structure critically involved in processing of social information-in children and adolescents with ASDs, as well as age-dependent changes and links with clinical symptoms.

Method

Resting-state functional magnetic resonance imaging (rs-fMRI) data from 55 participants with ASDs and 50 typically developing (TD) controls, aged 7 to 17 years, were included. Groups were matched for age, gender, IQ, and head motion. Functional connectivity MRI (fcMRI) analysis was applied to examine intrinsic functional con

SUBMITTER: Fishman I 

PROVIDER: S-EPMC6230473 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature