Imaging neurodegeneration in Down syndrome: brain templates for amyloid burden and tissue segmentation.

ABSTRACT: The focus of Alzheimer's disease (AD) neuroimaging research has shifted towards an investigation of the earliest stages of AD pathogenesis, which manifests in every young adult with Down syndrome (DS; trisomy 21) resulting from a deterministic genetic predisposition to amyloid precursor protein overproduction. Due to morphological differences in brain structure in the DS population, special consideration must be given to processing pipelines and the use of normative atlases developed for the non-DS population. Further, the use of typical MRI to MRI template spatial normalization is less desirable in this cohort due to a greater presence of motion artefacts in MRI images. The diffuse nature of PiB uptake and comparatively lower spatial resolution of the PET image permits the purposing of th

SUBMITTER: Lao PJ 

PROVIDER: S-EPMC6230506 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature