Lipid malabsorption from altered hormonal signaling changes early gut microbial responses.

ABSTRACT: Infants with congenital diarrheal disorders caused by enteroendocrine cell dysgenesis, or the loss of intestinal endocrine cells, causes severe malabsorptive diarrhea, though the mechanism is not fully understood. The transcription factor "aristaless-related homeobox" (Arx) is specifically expressed in intestinal endocrine cells. This study seeks to characterize the early malabsorptive phenotype of mice deficient for Arx using cell-type specific gene ablation in Villin-Cre; Arx^loxP/Y ( Arx^int) mice. In neonatal mice, the loss of intestinal Arx caused the loss of intestinal hormones, such as cholecystokinin, secretin, neurotensin, glucose-dependent insulinotropic peptide, glucagon-like peptide (GLP)-1 and GLP-2 but also upregulation of somatostatin. Arx^int m

SUBMITTER: Terry NA 

PROVIDER: S-EPMC6230693 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature