Exploring miRNA-mRNA regulatory network in cardiac pathology in Na⁺/H⁺ exchanger isoform 1 transgenic mice.

ABSTRACT: Numerous studies have demonstrated that Na⁺/H⁺ exchanger isoform 1 (NHE1) is elevated in myocardial diseases and its effect is detrimental. To better understand the involvement of NHE1, we have previously studied cardiac-specific NHE1 transgenic mice and shown that these mice develop cardiac hypertrophy, interstitial fibrosis, and cardiac dysfunction. The purpose of current study was to identify microRNAs and their mRNA targets involved in NHE1-mediated cardiac injury. An unbiased high-throughput sequencing study was performed on both microRNAs and mRNAs. RNA sequencing showed that differentially expressed genes were enriched in hypertrophic cardiomyopathy pathway by Kyoto Encyclopedia of Genes and Genomes annotation in NHE1 transgenic hearts. These genes were classif

SUBMITTER: Xue J 

PROVIDER: S-EPMC6230871 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature