New roles of aldosterone and mineralocorticoid receptors in cardiovascular disease: translational and sex-specific effects.

ABSTRACT: Recent advances in the field of mineralocorticoid receptor (MR) and its ligand aldosterone expanded the role of this hormone and its receptor far beyond their initial function as a regulator of Na⁺ and K⁺ homeostasis in epithelial cells. The symposium "New Roles of Aldosterone and Mineralocorticoid Receptors in Cardiovascular Disease: Translational and Sex-Specific Effects" presented at the 38th World Congress of the International Union of Physiological Sciences (Rio de Janeiro, Brazil) highlighted the contribution of extrarenal MRs to cardiovascular disease. This symposium showcased how MRs expressed in endothelial, vascular smooth muscle, and immune cells plays a critical role in the development of vascular disease associated with aging, obesity, and chronic aldoste

SUBMITTER: Davel AP 

PROVIDER: S-EPMC6230900 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature