TERT promoter mutations are associated with poor prognosis and cell immortalization in meningioma.

ABSTRACT:

Background

Meningiomas are mostly benign tumors tending to progress to higher-grade lesions. Mutations in the telomerase reverse transcriptase (TERT) gene promoter are comparably rare in meningioma, but were recently suggested to predict risk of recurrence and progression. Here we have analyzed a cohort of World Health Organization grades I-III meningiomas regarding the impact of TERT promoter mutations on patient prognosis and in vitro cell propagation feasibility.

Methods

From 110 meningioma patients, 128 tissue samples were analyzed for the TERT promoter mutations C228T and C250T by direct sequencing. Of the 128 samples, 121 were tested for cell propagation in vitro. Telomerase activity, TERT mRNA expression, and telomere lengths were investigated by telomeric repeat ampl

SUBMITTER: Spiegl-Kreinecker S 

PROVIDER: S-EPMC6231195 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature