DNA methylation-based classification of ependymomas in adulthood: implications for diagnosis and treatment.

ABSTRACT:

Background

Ependymal tumors are glial tumors that commonly manifest in children and young adults. Their classification has remained entirely morphological until recently, and surgery and radiotherapy are the main treatment options, especially in adults. Here we sought to correlate DNA methylation profiles with clinical and pathological characteristics in the prospective cohort of the German Glioma Network.

Methods

Tumors from 122 adult patients with myxopapillary ependymoma, ependymoma, anaplastic ependymoma, subependymoma, or RELA fusion-positive ependymoma classified according to the World Health Organization (WHO) 2016 were subjected to DNA methylation profiling using the Illumina HumanMethylation450 BeadChip platform. Molecular data were correlated with histologic featur

SUBMITTER: Witt H 

PROVIDER: S-EPMC6231197 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature