Optimal treatment for women with a persisting pregnancy of unknown location, a randomized controlled trial: The ACT-or-NOT trial.

ABSTRACT:

Objective

Pregnancy of unknown location (PUL) is not a diagnosis but a transient state used to classify a woman when she has a positive pregnancy test without definitive evidence of an intra-uterine or extra-uterine pregnancy on transvaginal ultrasonography. Management of a persisting PUL varies substantially, including expectant or active management. Active management can include uterine cavity evacuation or systemic administration of methotrexate. To date, no consensus has been reached on whether either management strategy is superior or non-inferior to the other.

Design

Randomized controlled trial.

Setting

Academic medical centers.

Patients

We plan to randomize 276 persisting PUL-diagnosed women who are 18 years or older from Reproductive Medicine Network cl

SUBMITTER: Barnhart KT 

PROVIDER: S-EPMC6231403 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature