Preliminary evidence of an association between increased cortical inhibition and reduced suicidal ideation in adolescents treated for major depression.

ABSTRACT:

Background

Suicide is a leading cause of death among youth. Prior research using transcranial magnetic stimulation (TMS) has implicated deficits in GABAergic cortical inhibition in adolescent suicidal behavior, yet no studies have assessed whether cortical inhibition varies over time in conjunction with changes in suicidal ideation (SI). This study examined dynamic changes in long-interval intracortical inhibition (LICI), a TMS measure of GABA_B-mediated inhibition, and their relationship with changes in SI in a small sample of adolescents undergoing pharmacologic treatment for depression.

Methods

Ten depressed adolescents (aged 13-17) underwent clinical assessment and TMS testing at baseline and again at follow-up. All were treated with antidepressant medication i

SUBMITTER: Lewis CP 

PROVIDER: S-EPMC6231405 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature