Managing the emergence of pathogen resistance via spatially targeted antimicrobial use.

ABSTRACT: From agriculture to public health to civil engineering, managing antimicrobial resistance presents a considerable challenge. The dynamics underlying resistance evolution reflect inherently spatial processes. Resistant pathogen strains increase in frequency when a strain that emerges in one locale can spread and replace pathogen subpopulations formerly sensitive to the antimicrobial agent. Moreover, the strength of selection for antimicrobial resistance is in part governed by the extent of antimicrobial use. Thus, altering how antimicrobials are used across a landscape can potentially shift the spatial context governing the dynamics of antimicrobial resistance and provide a potent management tool. Here, we model how the efficacy of adjusting antimicrobial use over space to manage antimicrob

SUBMITTER: Okamoto KW 

PROVIDER: S-EPMC6231480 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature