Intragenic Meiotic Crossovers Generate Novel Alleles with Transgressive Expression Levels.

ABSTRACT: Meiotic recombination is an evolutionary force that generates new genetic diversity upon which selection can act. Whereas multiple studies have assessed genome-wide patterns of recombination and specific cases of intragenic recombination, few studies have assessed intragenic recombination genome-wide in higher eukaryotes. We identified recombination events within or near genes in a population of maize recombinant inbred lines (RILs) using RNA-sequencing data. Our results are consistent with case studies that have shown that intragenic crossovers cluster at the 5' ends of some genes. Further, we identified cases of intragenic crossovers that generate transgressive transcript accumulation patterns, that is, recombinant alleles displayed higher or lower levels of expression than did nonrecomb

SUBMITTER: Liu S 

PROVIDER: S-EPMC6231493 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature