A Tf-modified tripterine-loaded coix seed oil microemulsion enhances anti-cervical cancer treatment.

ABSTRACT:

Purpose

A transferrin-modified microemulsion carrying coix seed oil and tripterine (Tf-CT-MEs) was developed for improved tumor-specific accumulation and penetration to enhance cervical cancer treatment.

Materials and methods

Tripterine-loaded coix seed oil microemulsion (CT-MEs) was prepared through one-step emulsion method. The morphology, size, and zeta potential of CT-MEs and Tf-CT-MEs were examined by transmission electron microscopy and dynamic light scattering. The cellular uptake and mechanisms of HeLa cells were investigated by flow cytometry. Intratumor penetration was investigated using a HeLa three-dimensional (3D) tumor spheroid as the model. The cytotoxicity of the CT-MEs and Tf-CT-MEs against HeLa cells were evaluated by the MTT assay. Additionally, the apopto

SUBMITTER: Chen Y 

PROVIDER: S-EPMC6231517 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature