Chromatin accessibility dynamics across C. elegans development and ageing.

ABSTRACT: An essential step for understanding the transcriptional circuits that control development and physiology is the global identification and characterization of regulatory elements. Here, we present the first map of regulatory elements across the development and ageing of an animal, identifying 42,245 elements accessible in at least one Caenorhabditis elegans stage. Based on nuclear transcription profiles, we define 15,714 protein-coding promoters and 19,231 putative enhancers, and find that both types of element can drive orientation-independent transcription. Additionally, more than 1000 promoters produce transcripts antisense to protein coding genes, suggesting involvement in a widespread regulatory mechanism. We find that the accessibility of most elements changes during developmen

SUBMITTER: Janes J 

PROVIDER: S-EPMC6231769 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature