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Midlife vascular risk factors and midlife cognitive status in relation to prevalence of mild cognitive impairment and dementia in later life: The Atherosclerosis Risk in Communities Study.


ABSTRACT: INTRODUCTION:The interplay between midlife vascular risk factors and midlife cognitive function with later life mild cognitive impairment (MCI) and dementia (DEM) is not well understood. METHODS:In the Atherosclerosis Risk in Communities Study, cardiovascular risk factors and cognition were assessed in midlife, ages 45-64 years. In 2011-2013, 20-25 years later, all consenting Atherosclerosis Risk in Communities participants underwent a cognitive and neurological evaluation and were given adjudicated diagnoses of cognitively normal, MCI, or DEM. RESULTS:In 5995 participants with complete covariate data, midlife diabetes, hypertension, obesity, and hypercholesterolemia were associated with late-life MCI and DEM. Low midlife cognition function was also associated with greater likelihood of late-life MCI or DEM. Both midlife vascular risk factors and midlife cognitive function remained associated with later life MCI or DEM when both were in the model. DISCUSSION:Later life MCI and DEM were independently associated with midlife vascular risk factors and midlife cognition.

SUBMITTER: Knopman DS 

PROVIDER: S-EPMC6231996 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature

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Midlife vascular risk factors and midlife cognitive status in relation to prevalence of mild cognitive impairment and dementia in later life: The Atherosclerosis Risk in Communities Study.

Knopman David S DS   Gottesman Rebecca F RF   Sharrett A Richey AR   Tapia Amanda L AL   DavisThomas Sonia S   Windham B Gwen BG   Coker Laura L   Schneider Andrea L C ALC   Alonso Alvaro A   Coresh Josef J   Albert Marilyn S MS   Mosley Thomas H TH  

Alzheimer's & dementia : the journal of the Alzheimer's Association 20180512 11


<h4>Introduction</h4>The interplay between midlife vascular risk factors and midlife cognitive function with later life mild cognitive impairment (MCI) and dementia (DEM) is not well understood.<h4>Methods</h4>In the Atherosclerosis Risk in Communities Study, cardiovascular risk factors and cognition were assessed in midlife, ages 45-64 years. In 2011-2013, 20-25 years later, all consenting Atherosclerosis Risk in Communities participants underwent a cognitive and neurological evaluation and wer  ...[more]

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