The Nucleolar Protein LYAR Facilitates Ribonucleoprotein Assembly of Influenza A Virus.

ABSTRACT: Influenza A viral ribonucleoprotein (vRNP) is responsible for transcription and replication of the viral genome in infected cells and depends on host factors for its functions. Identification of the host factors interacting with vRNP not only improves understanding of virus-host interactions but also provides insights into novel mechanisms of viral pathogenicity and the development of new antiviral strategies. Here, we have identified 80 host factors that copurified with vRNP using affinity purification followed by mass spectrometry. LYAR, a cell growth-regulating nucleolar protein, has been shown to be important for influenza A virus replication. During influenza A virus infection, LYAR expression is increased and partly translocates from the nucleolus to the nucleoplasm and cytoplasm. Fu

SUBMITTER: Yang C 

PROVIDER: S-EPMC6232469 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature