Susceptibility to Neutralization by Broadly Neutralizing Antibodies Generally Correlates with Infected Cell Binding for a Panel of Clade B HIV Reactivated from Latent Reservoirs.

ABSTRACT: Efforts to cure human immunodeficiency virus (HIV) infection are obstructed by reservoirs of latently infected CD4⁺ T cells that can reestablish viremia. HIV-specific broadly neutralizing antibodies (bNAbs), defined by unusually wide neutralization breadths against globally diverse viruses, may contribute to the elimination of these reservoirs by binding to reactivated cells, thus targeting them for immune clearance. However, the relationship between neutralization of reservoir isolates and binding to corresponding infected primary CD4⁺ T cells has not been determined. Thus, the extent to which neutralization breadths and potencies can be used to infer the corresponding parameters of infected cell binding is currently unknown. We assessed the breadths and potencies of

SUBMITTER: Ren Y 

PROVIDER: S-EPMC6232479 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature