Helicobacter pylori may be an initiating factor in newly diagnosed ulcerative colitis patients: A pilot study.

ABSTRACT:

Aim

To directly visualize Helicobacter pylori (H. pylori) by the highly sensitive and specific technique of immunohistochemical staining in colonic tissue from patients newly diagnosed with ulcerative colitis (UC).

Methods

Colonoscopic biopsies from thirty patients with newly diagnosed UC and thirty controls were stained with Giemsa stain and immunohistochemical stain for detection of H. pylori in the colonic tissue. Results were confirmed by testing H. pylori Ag in the stool then infected patients were randomized to receive either anti H. pylori treatment or placebo.

Results

Twelve/30 (40%) of the UC patients were positive for H. pylori by Giemsa, and 17/30 (56.6%) by immunohistochemistry stain. Among the control group 4/30 (

SUBMITTER: Mansour L 

PROVIDER: S-EPMC6232561 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature